翻訳と辞書 Words near each other ・ Sphoeroides rosenblatti ・ Sphingonaepiopsis nana ・ Sphingonaepiopsis obscurus ・ Sphingonaepiopsis pumilio ・ Sphingopus ・ Sphingopyxis ・ Sphingopyxis bauzanensis ・ Sphingopyxis flavimaris ・ Sphingopyxis granuli ・ Sphingopyxis italica ・ Sphingopyxis panaciterrulae ・ Sphingopyxis ummariensis ・ Sphingosine ・ Sphingosine beta-galactosyltransferase ・ Sphingosine cholinephosphotransferase ・ Sphingosine kinase ・ Sphingosine kinase 1 ・ Sphingosine N-acyltransferase ・ Sphingosine-1-phosphate ・ Sphingosine-1-phosphate receptor ・ Sphingosyl phosphatide ・ Sphingulini ・ Sphingulus ・ Sphinta ・ Sphinx ・ Sphinx (disambiguation) ・ Sphinx (documentation generator) ・ Sphinx (Dungeons & Dragons) ・ Sphinx (film) ・ Sphinx (gene) Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Sphingosine kinase ： ウィキペディア英語版 Sphingosine kinase Sphingosine kinase (SphK) is a conserved lipid kinase that catalyzes formation sphingosine-1-phosphate (S1P) from the precursor sphingolipid sphingosine. Sphingolipid metabolites, such as ceramide, sphingosine and sphingosine-1-phosphate, are lipid second messengers involved in diverse cellular processes. There are two forms of SphK, SphK1 and SphK2. SphK1 is found in the cytosol of eukaryotic cells, and migrates to the plasma membrane upon activation. SphK2 is localized to the nucleus. == Function == S1P has been shown to regulate diverse cellular processes. It has been characterized as a lipid signaling molecule with dual function. On one hand, it exerts its actions extracellularly by binding to the five different S1P receptors that couple to a variety of G-proteins to regulate diverse biological functions, ranging from cell growth and survival to effector functions, such as proinflammatory mediator synthesis. On the other hand, it appears to act as an intracellular second messenger, although the relevant molecular target(s) to which it binds within cells remains to be discovered. In any case, a role of S1P in various functions of cells and tissues is established, including regulation of cell survival and motility, angiogenesis, and inflammatory responses. Sphingosine kinases (SphKs) types 1 and 2, the two enzymes identified so far in mammals that produce S1P by ATP-dependent phosphorylation of sphingosine, have therefore received considerable interest. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Sphingosine kinase」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.